080 Mouse models of alopecia areata: C3H/HeJ mice versus the humanized AA mouse model
نویسندگان
چکیده
منابع مشابه
Mouse Alopecia Areata and Heart Disease: Know Your Mouse!
The proceedings of a recent meeting on alopecia areata (AA) (Bertolini et al., 2012) summarized work using the surgically induced C3H/HeJ mouse model for AA (McElwee et al., 1998), in which investigators found enlarged hearts in affected mice, suggesting an association between AA and cardiac findings. However, the heart lesions described are a well known strain specific disease, not limited to ...
متن کاملA mouse model of clonal CD8+ T lymphocyte-mediated alopecia areata progressing to alopecia universalis.
Alopecia areata is among the most prevalent autoimmune diseases, yet compared with other autoimmune conditions, it is not well studied. This in part results from limitations in the C3H/HeJ mouse and DEBR rat model systems most commonly used to study the disease, which display a low frequency and late onset. We describe a novel high-incidence model for spontaneous alopecia areata. The 1MOG244 T ...
متن کاملAlopecia Areata (AA, Patchy Hair Loss) — Causes and Treatment
Alopecia areata is a non-scarring hair loss disorder that can occur in any part of the body, ranging from a small patch to complete loss of hair, without significant age or sex predisposition. Although the exact etiology is unknown, several patient-specific genetic, immunological, and environmental factors have been implicated. The underlying pathology is probably peribulbar infiltration of CD4...
متن کاملAlopecia Areata (AA, Patchy Hair Loss) — Causes and Treatment
Alopecia areata is a non-scarring hair loss disorder that can occur in any part of the body, ranging from a small patch to complete loss of hair, without significant age or sex predisposition. Although the exact etiology is unknown, several patient-specific genetic, immunological, and environmental factors have been implicated. The underlying pathology is probably peribulbar infiltration of CD4...
متن کاملAnti-inflammatory effect of electroacupuncture in the C3H/HeJ mouse model of alopecia areata.
Accumulating experimental evidence has indicated that electroacupuncture (EA) stimulation may enhance immune function in several animal models of inflammatory diseases. 2 However, there are few clinical data on EA stimulation for autoimmune diseases and the mechanisms underlying the therapeutic effect of EA stimulation for autoimmune diseases remain unclear. Mast cells are the central players i...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2019
ISSN: 0022-202X
DOI: 10.1016/j.jid.2019.03.156